蝮蛇抗栓酶对失血性休克动物肾微循环血液灌流量的影响

Effect of agkistrodon antithrombotic enzymes (Svate) on renal microcirculatory perfusion in hemorrhagic shock animals

在40只失血性休克大鼠中静脉注射不同剂量的蝮蛇抗栓酶(0.05U,0.025U/100g B.W.)后用激光多普勒微循环血流量计测定肝、脾、肾、小肠及尾部微循环血流量,结果发现肾微循环血流量在用药后5～20分均有显著增加(P<0.05),在15只家兔的类似实验中同时测定肾表面微循环血流量与肾动脉血流量(电磁血流量计),结果发现静脉注射蝮蛇抗栓酶后(0.05U/ml/kg),肾动脉血流量并无明显增加,而肾皮质微循环血液灌流量显著增加,并与尿量增加一致。作者认为蝮蛇抗栓酶具有降低肾微循环血流阻力,加快流速,增加肾皮质微循环血液灌流量的作用。

The microcirculatory perfusion of liver, spleen, kidney, small intestine andtail were measured by a laser doppler flowmeter after intravenous injection of agkistro-don antithrombotic anzyme (0. 05 U, 0. 025 U/100 g B. W.) in 40 hemorrhagic shockrats and 15 hemorrhagic rabbits. The results showed that 5～20 min after injection therenal perfusion increased significantly, but there was no marked increase of renal arteryblood flow when it was simultanously detected with a electromagnetic flowmeter, thoughthe urine was increased. Authors suggested that Svate may have decreased the resistenceof renal microcirculation and accelerate the veosity of renal microcirculation, thus theyincreased the microcirculatory perfusion in renal cortex.