长期应用巯甲丙脯酸对心肌梗塞大鼠心脏构筑与左室功能的影响

The effects of long term captopril administration on cardiac morphology and left ventricular function of rats with infarction

为探讨心肌梗塞(MI)后长期应用巯甲丙脯酸(Cap)对心脏构筑与左室功能的影响,MI鼠与假手术鼠自术后第三天通过饮水给予Cap五周。结果表明,Cap可明显降低MI鼠与假手术鼠的左室重量与体重的比值,并使两组大鼠尤其是MI鼠每核平均心肌细胞体积明显缩小,心肌细胞长度与直径也相应变小,但对两组心室构型的影响不同,主要表现为给药MI鼠左室腔容积明显缩小。Cap对MI鼠基础状态和容量负荷下的心脏指数(CI)无明显影响。但由于给药后左室腔半径缩小,LVEDP降低,提示其射血分数增加。表明MI后长期应用Cap虽可明显抑制代偿性心肌肥大,但由于左室腔缩小及负荷降低,心功能反而有所改善。

To determine the effects of long term captopril administration on cardiacmorphology and left ventricular function in rats with myocardial infarction, captopril wasadministered to rats 3 days after the begining of myocardial infarction and continued for35 days. Captopril lowened the ratio of left ventricular weight to body weight of bothrats with and without infarction, and also reduced volume, length and dimention of myo-cyte. Captopril had special effects on ventricular geometry in rats with infarction, whichresulted in decreased radius of left ventricular cavity. The cardiac index of captopril-treatedrats with infarction during baseline and a volume loading didn’t change, whereas the ra-dius of left ventricular cavity and LVEDP were decreased significantly, which indicated anincrease of the ejection fraction index. The results showed that long term administrationof captopril might be unfavoralle to compensary myocardial hypertrophy, but catdiacfunction was improved, which was ascribed to reduction of left ventricular cavity volumeand LVEDP.