多囊卵巢综合征妇女内源性胰岛素释放与睾酮反应的相关性研究

Study on correlation between endogenous insulin release and testosterone response in women with PCOS

本研究以36例PCOS妇女和20例正常月经周期妇女为研究对象。通过测定激素基础水平,观察在糖耐量试验中胰岛素对糖负荷的反应和睾酮的变化以及分析体脂与胰岛素的关系。发现PCOS妇女有较高的空腹血糖水平、空腹血清胰岛素与空腹血清睾酮呈显著正相关(r=0.65,P<0.01)。在糖负荷期PCOS组血清胰岛素释放显著高于对照组(P<0.01),同时,总睾酮与总胰岛素呈正相关(r=0.69,P<0.01)。PCOS肥胖者总胰岛素对糖负荷的反应最大,对照非肥胖者反应最小(F=3.02,P<0.01)。PCOS妇女体脂百分率与空腹血清胰岛素呈正相关(r=0.523,P<0.05)。由此提示(1)PCOS妇女内源性胰岛素释放是PCOS雄激素增高的原因之一;(2)PCOS妇女体脂过多可能在PCOS的高胰岛素血症和胰岛素抵抗中起有部分作用。

36 women with PCOS (polycystic ovary syndrome) and 20 women withregular cycles were investigated in this study, by measurement of basic hormone levels,observation of alteration of testosterone and insulin response to glucose challenge duringglucose tolerance and analysed the percentage of body fat (BFP). Increase of fastingblood glucose levels and a significant positive correlation between fasting serum insulinlevels and fasting serum testosterone levels (r=0.65, P<0.01) were verified in womenwith PCOS. It was found that the maximum level of insulin release in PCOS groupduring glucose challenge were very much higher than that of control group (P<0.01),meanwhile, there was a definite positive correlation between total insulin response and totaltestosterone (r=0.69, P<0.01) in PCOS group. We found an extremely high insulinresponse in obese-PCOS women, but little in nonobese control women (F=3.02, p<0 .01).Also was a positive correlation between BFP and fasting serum insulin levels (r=0.523,P<0.05) in women with PCOS. In summary, these results suggested that (1) Endogenousinsulin release was one of the causes of hyperandrogenism in women with PCOS, and (2)excess body fat might play a role in hyperinsulinemia and insulin resistance of PCOS.