哮喘时下呼吸道和血液中P物质含量的变化

Alteration of substance P in the lower respiratory tract and blood of asthmatic guinea pi

应用放射免疫分析方法,测定了16只哮喘豚鼠下呼吸道和血液中P物质的水平,与健康对照组的结果(气管含量为1.83±0.20、支气管为2.35±0.28、左肺上叶为2.87±0.35pmol/g湿重,血液为211±39pg/mld,X±SE)相比较,哮喘豚鼠下呼吸道和血液中P物质水平(气管2.76±0.46、支气管3.54±0.29、左肺上叶4.42±0.53pmol/g湿重,血液428±58pg/ml,X±SE,各项P<0.01)显著升高。结果提示,P物质可能参与哮喘发病的病理生理过程,可能是其发作的因素之一。

The value of substance P in the lower respiratory tract circulatingblood of 16 experimental asthmatic guinea pigs has been measured using radioimmunoas-say. The substance P levels of the asthmatic guinea pigs (trachea 2.76±0.46, brnchus3.54±0.29, upper lobe of left lung 4.42±0.53 pmol/g wet tissue, blood 428±58 pg/ml,X±SE, P<0.01) were much higher than that of the normal controls (trachea 1.83±0.20, bronchus 2.35±0.28, upper lobe of left lung 2.87±0.35 pmol/g wet tissue, blood211±39 pg/ml, X±SE). These data suggested that substance P may Play an importantrole in the pathogenesis of asthma, and that a theoretical basis was provided for the treat-ment of asthma by using substance P antagonist or inhibitor of its receptor.