内生致冷原对家兔内毒素性发热的影响

The effect of EC on the ET-induced fever in rabbits

本文通过给家兔静脉注射分离纯化的EC,,观察了EC对正常体温、ET性发热时体温及血清Fe^(2+)、Zn^(2+)、Cu^(2+)含量的影响。结果显示,EC能降低正常体温及ET性发热时升高的体温;同时,EC能抑制ET性发热的第二热峰的形成;但EC不能拮抗ET引起的血清Fe^(2+)、Zn^(2+)、Cu^(2+)含量的改变。上述结果提示,EC可能参与了正常及发热时的体温调节过程,但可能不参与ET所致的其它急性期反应调节。

The effects of intravenous injection of purifed EC on the rectal tempera- ture in normal rabbits and febrile rabbits induced by ET and concentrations of Fe^(2+), Zn^(2+), Cu^(2+) in serum were observed. The results showed that EC could lower the rectal tempera- ture in normal rabbits and also the increased rectal temperature in febrile rabbits. Mean- while, EC could inhibit the formation of the second phase of ET-fever. But EC had no effect on the changed concentrations of FC^(2+), Zn^(2+), Cu^(2+) in serum caused by ET. These findings suggest that EC may particiate in the regulation of body temperarure under physio- logical and febrile conditions, but not of acute phase response produced by ET.