降钙素基因相关肽对定量冠脉狭窄后冠脉血流动力学的作用

Effects of CGRP on coronary hemodynamics following graded coronary stenosis

本实验用犬冠脉定量狭窄模型,观察了由冠脉注射降钙素基因相关肽(CGRP)对犬正常及不同程度冠脉狭窄时的冠脉血流动力学的影响,结果表明,冠脉内注射CGRP(0.3μg/kg)可使冠脉血流量(CBF)和远端小动脉压(DCP)有不同程度增加,平均动脉压(MAP)轻度下降,冠脉血管总阻力(R_T)、大冠脉血管阻力(R_L)及小冠脉血管阻力(R_S)减小。在中度冠脉狭窄30min后注射CGRP,MAP无明显改变,CBF增高,而DCP、R_T、R_L、R_S均降低,且持续30min;在重度狭窄30min后注射CGRP,CBF明显增加,MAP由狭窄后降低变为逐渐增高,DCP、R_T、R_L、R_S持续降低。该结果提示CGRP可扩张冠状动脉,增加冠脉血流量,从而使心肌供血得到改善。

Intracoronary effects of calcitonin gene related peptide (CGRP) on coro-nary hemodynamics were observed in the normal and following different extent of coro-nary stenosis using graded coropary- stenosis modl in dogs. The results showed that CGRPincreased the coronary artery blood flow (CBF) and distant coronary blood prepsure (DCP),but decreased mean artery pressure (MAP), coronary vessels total resistance (R_T),large co-ronary vessels, resistance (R_L) and small coronary vessels resistance (R_s). Thirty minutesafter. coronary middle. stenosis, CGRP was given intracoronary, MAP had no significantchange, but CBF insreased and R_T R_L, R_s decreased, and which maintained for 30 min. 30min after coronary severe stenosis, CGRP increased CBF and MAP, but decreased DCP,R_T, R_L, R_S continuously. These results suggested that CGRP could ameliorate myocardialischemia through enlargement of coronary vessels and by increasing CBF.