钙通道阻滞剂对内毒素性发热的抑制作用

The effect of the calcium-channel-blocking agent on the febrile response induced by ET

本实验用新西兰家兔61只,观察钙通道阻滞剂异博定对内毒素性发热及脑脊液中PGE_2、cAMP含量的影响。结果显示:异博定能降低内毒素引起的体温升高及脑脊液中升高的PGE_2含量,但不能明显降低脑脊液中升高的cAMP含量。作者认为,异博定的降热作用很可能是通过抑制下丘脑PGE的合成而减弱其发热效应的,而cAMP可能不参与其降热机制。

This experiment was carried out in 65 New Zealand rabbits. The resultsrevealed that the febrile response and increaed PGE_2 level in cerebrospipel fluid (CSF) were significantly reduced when the calcium-channel-blocking agent (verapamil) wasintravenously injected prior to ET. But, verapamil had no marked effect on the increasedcAMP level in csf during ET-induced fever. It was suggested that most likely this anti-pyretic action was due to the effect on biosynthesis of PGE in hypothalamus, while,cAMP might not be involved in the mechanism of this antipyretic action.