摘要
采用腹腔内注射庆大霉素造成大鼠急性肾小管损伤模型,发现中药淫羊藿、虫草菌丝和黄芪均可以减轻庆大霉素所致的大鼠肾小管及肾间质的损伤,并可拮抗庆大霉素对大鼠肾皮质Na^+-K^+-ATP酶的抑制作用。
Animal model of aged rat nephrotoxicity was induced by i. p. administrationof gentamycin in a dose of 140mg/kg/day. Part of those rats were treated with CordycepsSinensis(CS), Epimedium(Ep) and Astragalus Membranaccus (AM) in form of decoc-tion per Os and others seryed as control. The results were summarized as. 1. The nephro-toxicity of gentamycin was aggrevated with age. CS, Ep and AM are effective drugs inpreventing the tdeular damage caused by gentamycin in rats. The pathological changes ofrenal tuoules of the rat groups which treated with CS, Ep and AM were less severe thanthat of the control. 2. CS, Ep and AM could prevent the decline of renal cortical Na^+-K^+-ATPase activity of aged rat induced by gentamycin.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1993年第6期758-760,共3页
Chinese Journal of Pathophysiology
关键词
庆大霉素
肾
腺苷三磷酸酶类
Gentamycins
Kidney
Na^+-K^+-ATPase adenosine triphosphatase