ITP患者血小板内β-TG含量与血小板聚集功能及出血程度的关系

Studies of platelet β-thromboglobulin content, platelet aggregation and bleeding tendency in patients with ITP

应用放射免疫分析法测定43例特发性血小板减少性紫癜(ITP)患者血小板内β-TG含量,结合血小板聚集功能及PAIgG测定,探讨这些指标与出血程度之间的关系。发现血小板聚集功能与血小板内β-TG含量之间存在正相关,血小板内β-TG含量低者出血较明显;ITP患者的血小板聚集功能减低并非因PAIgG从空间上阻碍了致聚剂在血小板上的结合部位所致,而是与血小板贮存池缺陷有关。

Platelet β-thromboglobulin content was determined by radioimmunoassayin 43 patients with idiopathic thrombocytopenic purpura (ITP). Platelet aggregation andPAIgG were detected simultaneously in 16 and 12 or the patients respectively. It wasfound that there was a positive correlation between platelet aggregation rate and plateletβ-thromboglobulin content and that patients with lower platelet β-thromboglobulin con-tent showed more severe bleeding tendency and impaired platelet aggregation. It was sug-gested that the defect of platelet aggregation in ITP did not result from anti-platelet anti-body-mediated steric inhibition of inducer binding site, but from storage pool deficiency ofplatelet. We concluded that platelet β-thrombogloboulin content was a valuable parameter indetermining platelet quality, platelet aggregation and also in predicting bleeding tendencyof the patients.