乙型肝炎患者干扰素抗体的检出及其意义

Detection and Its Significance of Interferon-α Antibodies in Patients with Hepatitis B

目的 研究乙型肝炎患者的血清中干扰素 (IFN -α)抗体的检出率及其意义。方法 将研究对象分为正常对照组 ,急、慢性乙肝及肝炎肝硬化组 ,用酶联免疫测定法检测各组的血清IFN抗体阳性率 ,进行统计分析。结果 急性乙肝组IFN抗体检出率较对照组无显著变化 ,慢性乙肝和肝炎肝硬化组显著增高 ,用IFN -α治疗第 3个月IFN抗体显著增加。结论 长期的乙肝病毒感染者存在免疫功能紊乱 。

Objective To study the positive rate of interferon-α antibodies and its significance in patients with hepatitis B.Methods Detecting interferon-α antibodies in serum with ELISA in the control group, the acute and the chronic hepatitis B and the cirrhosis group.Results There were no significant differences in the positive rates of interferon-α antibodies between the control group and the acute hepatitis B group, but the positive rate significantly increased in the chronic hepatitis B group and the cirrhosis group. After treating with IFN-α for 3 months, the positive rates of interferon-α antibodies significantly increased.Conclusions There was immunologic function disturbance in patients with long-term hepatitis B virus infection.