营养不良大鼠左心功能的改变与克山病病因关系的探讨

By measuring cardiac function of malnutrition Rats to observe the causes of Keshan disease

以左室收缩压峰值LVSP、左室内压最大上升速率dp/dt_(max)、E_(max)等指标测定了饲以克山病区(山东邹县)地瓜干煎饼三个月的营养不良大鼠的左心收缩功能及心脏容量负荷耐受性。结果:28只营养不良大鼠的心率HR、LVSP、dp/dt_(max)、E_(max)分别为295±59beats/min、12.4±3.8Kpa、279.3±104.9Kpa/sec、13.4±4.7Kpa/mm。皆明显低于正常对照 P<0.01。大剂量生理盐水快速静脉注射后上述指标明显低于注射前。P<0.01,而正常大鼠无明显改变 P>0.05。结果表明:营养不良大鼠左心收缩功能降低,容量负荷耐受性减弱。从而从心肌功能水平为营养不良因素在克山病发病中的作用提供了实验依据。

To evaluate the possible role of malnutrition in relation to Keshan disease,cardiac function of 28 malnutrition rats were measured.The results were as follows:the values of HR LVSP dp/dtmax Emax of malnutri-tion rats were:295±59 beats/min 12.4±3.8Kpa 279.3±104.9Kpa/sec 13.4±4.7Kpa/mm((?)±s)re-spectively and were all lower significantly than that of normal rats(p<0.01).When volume load increased,the above values were decreased significantly(p<0.01).These results suggest that:Cardiac contractility andload tolerance of cardiac muscle of malnutrition rats were reduced,and these provided evidences for Keshandisease in relation to malnutrition.