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微生物来源的Azole类抗真菌活性增强剂——FKI-0076A、B和C的研究 被引量：4

Studies on FKI-0076A,B,C——synergists of azoles antifungal antibiotics from microorganisms
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摘要 FKI- 0 0 76 A、B和 C是从真菌培养液中筛选 Azole类抗真菌活性增强剂过程中获得的 ,每 6 mm纸片 10μg FKI- 0 0 76 A、B或 1.0μg FKI- 0 0 76 C就显示增强活性。真菌 Talaromyces sp.FKI- 0 0 76培养 5 d后 ,经有机溶媒提取 ,常压 ODS柱层析和制备 HPL C柱层析分离 ,得到 FKI- 0 0 76 A、B和 C纯品。又经过测定其HR- MS、UV、IR、1 H- NMR、1 3C- NMR、DEPT、1 H- 1 H COSY、HMQC和 HMBC等光谱数据。将 FKI- 0 0 76 A的结构定为 BK 2 2 3- A,FKI- 0 0 76 B的结构定为 vermistatin,FKI- 0 0 76 C的结构定为 deoxyfunicone。 During our screening programme for synergist of azoles antifungal antibiotics, we found the FKI 0076A, B and C which exhibited 10, 10 and 1.0μg/6mm paper disk of synergistic activity to azoles. The culture broth of Talaromyces sp. FKI 0076 for 5 days in shaking state was extracted by organic solvent, isolated by Open ODS Column and HPLC, active compounds FKI 0076A, B and C were obtained. Based on spectral data of HR MS, UV, 1 H NMR, 13 C NMR, DEPT, 1 H 1H COSY, HMQC and HMBC, FKI 0076A, B and C were identified as BK 223 A, vermistatin and deoxyfunicone,respectively.
作者 王海燕 荒井雅吉 供田洋 大村智
机构地区 中国医学科学院中国协和医科大学医药生物技术研究所 日本国北里研究所
出处 《中国抗生素杂志》 CAS CSCD 北大核心 2001年第2期89-93,133,共6页 Chinese Journal of Antibiotics
关键词 Azole类 Azole类活性增强剂 FKI一0076A BK 223一A FKI一0076B Vermistatin FKI-0076C Deoxyfunicone Azoles Synergist of Azoles FKI 0076A BK 223 A FKI 0076B Vermistatin FKI 0076C Deoxyfunicone
分类号 R917 [医药卫生—药物分析学]
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参考文献10

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同被引文献29

  • 1沈亮亮,叶元康.氟康唑与5-氟胞嘧啶体外联合抗白念珠菌临床分离株的研究[J].同济大学学报（医学版）,2005,26(6):19-21. 被引量：10
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中国抗生素杂志
2001年 第2期

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