西咪替丁预防新生儿急性胃粘膜病变临床观察

Cimetidine in prevention of acute gastric mucosal lesion of newborns

目的 :观察西咪替丁预防新生儿急性胃粘膜病变 (AGML)的效果。方法 :83例重症新生儿根据原发疾病分成两组。观察组 43例 ,对照组 40例。两组患儿常规治疗相同 ,观察组加用西咪替丁 5mg/kg静脉滴注 ,疗程 5天。 结果 :观察组AGML的发生率明显低于对照组 (P <0 .0 5 )。结论

Objective:To observe the effect of cimetidine on acute gastric mucosal lesion(AGML) of newborns.Methods:Eighty three cases were divided into 2 groups according to their original diseases.Forty three were added cimetidine 5 mg/kg per day for 5 days while the other 40(controls) were not.The routine management for both groups was the same.Results:The occurence of AGML in the group with cimeitidine was significantly lower than that in the control group( P <0.05).Conclusions:Cimetidine can lower the rate of AGML of newborns.