载脂蛋白E基因多态性与老年人认知功能相关性研究

The Study of Correlation Between Senile Cognitive Ability and Apolipoprotein E Genotype

目的 研究载脂蛋白E(ApoE)基因多态性与老年人认知功能之间的相关性。方法 采用简易精神状态检查(MMSE)对134例住院患者作认知功能评分,分为MMSE≤23组和MMSE≥24组,做ApoE的基因分型鉴定并进行比较。结果 MMSE≥24组,ApoEε3/ε3型占77.8％,MMSE≤23组,ApoEε3/ε3型占52.1％。ApoEε4/ε3型频率(28.8％)和ApoE ε4等位基因频率(17.6％)均高于MMSE≥24组,两组相比有显著性差异(P<0.01)。在MMSE≤23组中男女患者相比ApoEε4等位基因频率和年龄均无显著性差异(P>0.05),而女性患者在MMSE≤23组中的人数比男性患者多,有显著性差异(P>0. 05)。结论 无痴呆老年人的认知功能与ApoE基因型存在关联性,ApoEε4等位基因是对老年认知功能产生有害影响的因素,可能不是AD所特有的。ApoEε4等位基因频率分布无性别差异。

Objective To study the correlation between ApoE gene polymorphism and senile cognitive ability. Methods To determine the senile cognitive ability of 134 in -patients by MMSE,then they were divided into MMSE≤23 group and MMSE≥24 group. Their ApoE allele genotype were detected and contrasted. Results The ApoE ε 3/ε 3 phenotype was more common in the MMSE≥24 group,accouting for 77. 8% . But the ApoE ε 3/ε 3 phenotype accounted for 52. 1 % in the MMSE≤23 group, the frequencies of ApoE ε 4/ε 3 phenotype (28.8%)and ApoE ε 4 alleles (17.6%)were higher than that in the MMSE≤23 group, the differences were significantly in statistics( P < 0. 01). There was no significant difference in the frequency of ApoE e 4 allele gene and age between female and male in the MMSE≤23 gruop( P > 0.05), but female were predominant ( P < 0. 05). Conclusions The correlation between ApoE genotype and cognitive ability in senile patients without aphrcnia. ApoE e 4 allele gene could be regarded as a harmful factor to senile cognitive ability. There is no difference in the frequency of ApoE e 4 allele gene between the male and the female.