多发梗死性痴呆与阿尔次海默病认知功能损害及有关因素的比较研究

The Control Study of Cognitive Function Impairment and Correlate Factors in the Patients with Multi-In-farct Dementia (MID) or Alzheimer' s Diease (AD)

目的探讨多发梗死性痴呆(MID)与阿尔次海默病(AD)在认知功能损害及有关因素方面的差异,为早期诊断、鉴别诊断提供依据。方法 对113例MID患者与78例AD患者作简易智力状态检查量表(MMSE)测查,及研究其发病有关因素并作比较。结果 MMSE总分MID组为(17.43±6.1)分高于AD组的(13.30±5.30)分;定向力、语言命名、注意计算、短程记忆、物体命名、语言复述、阅读理解、语言表达、图形描记因子分MID组均高于AD组;MID组平均血压值高,高血压史、中风史、局灶性神经系统体征明显,急性、亚急性起病、病程呈波动特点为多。结论 MMSE测查结果结合有关病史是MID早期诊断及与AD鉴别诊断的重要依据。

Objective To explore the differences the patients with Multi - Infarct Dementia(MID) and the patients with Alzheimer's Disease(AD) in cognitive impairment and Correlate factors. Methods 113 patients with MID(MID group) and 78 patients with AD(AD group) were evaluated by Mini- Mental State Examination(MMSE), while the correlate factors were also Compared. Results There was significant difference between the two groups, the average score of MID group was 17. 43 ± 6. 10, that of AD group was 13.30 ±5.30, P <0.001. The scores of MID group were more higher than AD group in the following items: orientation,using of language,attention and calculation,short - term memory,naming,repeating,reading and comprehension,expression of language and copy design[ P < (0. 05 -0. 001)]. On the other hand, higher averge blood pressure,hypertensive history,history of stroke,positive signs of nerve system,acute or subacute onset and fluctuating process were the features of MID patients. Conclusions The result of MMSE examination, combining the disease history were quite important in early diagnosis of MID and early differential diagnosis from AD.