维生素E对再灌注心律失常的预防作用

Preventive Effects of Vitamin E on Reperfusion Arrhythmias

60只麻醉开胸 SD大鼠 ,可逆结扎左冠状动脉主支 5 m in后解除结扎 6 0 m in,引发再灌注心律失常 (RA) ,动物分为生理盐水 (NS,10 m l/kg,ig)、维生素 (VE,5 0 0 m g/kg,ig)与超氧化物歧化酶 (SOD 5 0 0 0 U /kg,iv) 3组。用 RM-6 0 0 0多导生理记录仪监测 ECG 。结果 NS与 SOD组 RA总发生率均为 95 % ,V E组为 35 % (P<0 .0 0 1)。 N S,SO D及 VE组心室纤颤发生率与死亡率分别为 45 ,40 % ;5 0 ,2 5 % ;15 ,0 %。 V E组显著比 NS。

Reperfusion arrhythmias(RA) were induced in 60 open chest anaesthetized Sprague Dowley rats by reversible ligation of the left coronary artery for 5 min and subsequent release for 60 min.The experimental animals were divided into three groups:normal saline(NS,10ml/kg ig),vitamin E(VE,500 mg/10 ml·kg,ig),and superoxide dismutase (SOD,5000 U/2.5ml·kg,iv).ECG was monitored with RM 6000 Polygraph.The results were as follows:the total incidence of RA was 95% in both NS and SOD groups,with only 35% in VE group (P<0.001).The incidence and mortality of ventricular fibrillation(VF) were 45% and 40% in NS group,50% and 25% in SOD group and 15% and 0% in VE group,respectively.Compared with those in the NS and SOD groups,the incidence and mortality of VF in the VE group were significantly lowered.