国产血竭的化学成分研究

Chemical constituents of Sanguis Draxonis made in China

目的 研究国产商品血竭的活性成分。方法 用甲醇提取 ,Sephadex L H- 2 0、MCI gel和硅胶柱色谱分离国产商品血竭中的化学成分 ,用现代波谱方法进行结构鉴定。结果 从国产雨林牌血竭的甲醇浸提物中分离并鉴定了 12个化合物 ,它们分别为 :2 6 - O-β- D-葡萄吡喃糖基 -呋甾烷 - 5 ,2 5 (2 7) -二烯 - 1β,3β,2 2β,2 6 -四醇 - 1- O-α- L -阿拉伯吡喃糖苷 ( ) ,3,4-二羟基烯丙基苯 - 4- O- β- D-葡萄吡喃糖苷 ( ) ,7-羟基 - 3- (对 -羟基苯基 ) -色原烷 ( ) ,7,4′-二羟基 - 3′-甲氧基黄烷 ( ) ,3,4-二羟基烯丙基苯 ( ) ,白藜芦醇 ( ) ,7,4′-二羟基二氢黄酮 ( ) ,二对羟基苯基甲烷( ) ,五加苷 B( ) ,对羟基苯甲酸 ( ) ,对羟基苯酚 ( )和原儿茶醛 ( )。结论 化合物 为一新的甾体配糖体 , 为一新酚苷 , ～ 为首次从该植物中分得。

Object To study the active constituents of Sanguis Draxonis made form Dracaena cochinchinensis (Lour ) S C Chen in China * Methods Various column chromatographies with Sephadex L 20 gel, MCI gel and silica gel were employed for the isolation and purification The structures of compounds were elucidated by spectral analysis Results Twelve compounds were isolated from the commercial product available on the market By means of spectral data, they were identified as 26 O β D glucopyranosyl furostan 5,25 (27) diene 1β,3β,22β,26 tetrahydroxy 1 O α L arabinopyranoside (Ⅰ); 3, 4 dihydroxy allylbenzene 4 O β D glucopyranoside (Ⅱ); 7 hydroxy 3 (p hydroxyphenyl) chroman (Ⅲ); 7, 4′ dihydroxy 3′ methoxyflavan (Ⅳ); 3, 4 dihydroxyallylbenzene (Ⅴ); resveratrol (Ⅵ); 7, 4′ dihydroxy flavanone (Ⅶ); di (p hydroxyphenyl) methane (Ⅷ); acanthoside B (Ⅸ),p hydroxybenzoic acid (Ⅹ); hydroquinone (Ⅺ) and protocatechualdehyde ( ⅩⅡ ) Conclusion Compound Ⅰ and Ⅱ are new natural glycosides, and Ⅴ and Ⅵ are isolated from D cochinchinensis for the first time