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P-糖蛋白在血脑屏障上的作用及其对肿瘤多药耐药的介导机制

Effect of P-glycoprotein and its Interposing Mechanism of Drug-Resisting for Tumor at Blood-Brain Protective Screen
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摘要 综述P -糖蛋白 (P -gp)的生物学特性及其在血脑屏障上对药物通透性的影响。说明P -gp是一种能量依赖性主动外排泵。mdrl基因编码的P -糖蛋白 (P -gp .P170 )过度表达可能介导了肿瘤细胞的多药耐药 (MDR)。指出 ,进一步研究对于提高抗癌药的疗效 ,改善药物的中枢作用和毒性 ,提高机体正常细胞的抗毒能力 ,减少毒副反应等都有重要的意义。
作者 令红艳 李军 唐刘红
机构地区 乐山卫校药理教研室 乐山市计划生育指导所 乐山市医学科技情报所
出处 《四川省卫生管理干部学院学报》 2001年第4期284-285,共2页 Journal of Sichuan Continuing Education College of Medical Sciences
关键词 P-糖蛋白 血脑屏障 肿瘤 多药耐药
分类号 R961 [医药卫生—药理学]
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参考文献15

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二级参考文献8

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四川省卫生管理干部学院学报
2001年 第4期

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