原发性肝癌的遗传因素分析

Study of Hereditary Factor of Hepatocellular Carcinoma

对陕西地区110例原发性肝癌(肝癌)患者按配对病例对照的设计方法进行了遗传流行病学研究。结果显示该地区肝癌的遗传度为27.6±3.6％,分离比为0.0016～0.0095。提示本地区肝癌发生中遗传因素所起的作用较小,并且不符合单基因的遗传方式。乙肝病毒(HBV)感染与癌家族史的分层分析表明HBV感染与癌家族史具有协同作用。分子遗传学分析表明,肝癌患者淋巴细胞DNA受诱癌剂作用后其UDS值明显增高,并且这种升高只表明在有癌家族史的肝癌患者中,提示肝癌的遗传易感染性可能与细胞DNA易受诱癌剂损伤和损伤后非程序合成增加有关。

110 hepatocellular carcinoma (HCC) cases and 110 non-cancer controls in Shanxi were invsetigated by method of Genetic epidemology. The result showed that HBV infection had synergtic action with family cancer history. With LiMantle-Gart method, segregation ratio of HCC in siblings was about 0.0016~0.0095, Suggesting that HCC can be hereditary disease of multigene. With Falconer's mul- tifcatorial threshold model, heritability (h^2) of HCC was 27±3.6%. Comparing unscheduled DNA synthesis (UDS) values of HCC with that of normal controls who had no family cancer history, it was found that, after actvated by the carcinogen NH2HCL, UDS of lymphocyte of HiCC was higher than control. The result of stratification analysis showed that UDS of HCC having family cancer history was high than of control, but UDS of HCC not having family cancer history was not significant difference, showing that hereditary susceptibility of HCC was related to that DNA of cells was easy damaged by the inducer of cancer and after damaging unscheduled DNA synthesis was incr- eased.