丙烯酰胺对雄性小鼠生殖系统的影响

Effect of Acrylamide Monomer on Genital System of Male Mice

本文运用睾丸染色体畸变试验和精子畸形试验研究了丙烯酰胺对雄性小鼠生殖系统的影响。试验组剂量分别为21.25、42.5、85mg/kg。丙烯酰胺所致的畸变最低剂量精原细胞为85mg/kg,精母细胞和精子畸形均为42.5mg/kg,并有一定的剂量-反应关系。实验结果表明丙烯胺中剂量和高剂量能引起生殖细胞畸变和精子畸形,但低剂量组(21.25mg/kg)未见明显的致突变作用。

In this paper, the effects of anrylamide mo- nomer on genital system in male mice was stu- died by means of sperm morphology and chro- mosomal aberrations in germ cells of testis. Male mice were given the acrylamide monomer in doses of 21.25, 42.5, 85mg/kg by intraperito- heal injection. The least dose of acrylamide monomer was 85mg/kg for the mutagenic induct- ion of spermatogonia, 42.5mg/kg for that of pr- imary spermatocyte and sperm shape. There was a difinite relationship between dose and re- sponse. The result indicated that acrylarnide m- onomer was mutagenic to germ cells and sperm of testis in middle and high dose while no sign- ificant mutagencity was found at lower exposu- re level (21,25mg/kg).