空气氯乙烯污染与人群免疫效应

Immunological Effects of Air Vinyl Chloride Pollution to Population

为观察空气氯乙烯(VC)污染对人群免疫功能的影响,采用E玫瑰花结(E—RFT)、嗜中性粒细胞吞噬功能试验及PHA皮试,对12名VC作业工人及10名VC居住区儿童分别进行配对研究。结果表明:接触VC>30mg/m^3的作业工人的几项细胞免疫指标均明显低于对照(P<0.01),VC≥0.18mg/m^3儿童的E·RFT低于对照(P<0.01),E—RFT下降的程度有随VC接触量的增加而加重的趋势;VC≤0.08mg/m^3对照的E—RFT已接近于正常上限。提示:空气VC≤0.08mg/m^3可作为VC无作用阈浓度;E—RFT是观察人群细胞免疫效应较灵敏的指标;细胞免疫指标可作为VC职业人群健康监护的项目之一。

A exposure-control study of 10 children (aged 10 to 12) and 12 workers exposed to vinyl chloride(VC)are reported by using the informed erythrocyte rosette forming test(E- RFT), neutrophilic granulocyte phagocytosis (NGP) test and phytohemagglutinin (PHA) skin test as immunological indexes in order to observe the effects of air VC pollution to the immune function of the population. The re- sults show that all cellular immunological in- dexes in workers exposed to VC concentration more than 30mg/m^3 are significantly lower than control (p<0.01) and the cellular toxici- ty are shown. The E-RFT in children ex- posed to VC concentration no less than 0. 18mg/m^3 is significantly lower than that of control (p<0. 01) and the Tecell function is inhibited. The degree of E-RFT decreased a- gree with that of VC contact amount in- creased. The E-RFT of the group exposed to VC concentration less than 0. 08mg/m^3 are similar with upper part of normal ERFT. The study shows that the air VC concentration no more than 0.08mg/m^3 can be recommended as noeffect level and E-RFT is a sensitive index of cellular immune effect on population and the cellular immune index can be used as one of subjects for monitoring VC occupationally exposed population.