海南省吊罗山地区恶性疟原虫对咯萘啶、磺胺多辛、乙胺嘧啶联用敏感性的5年监测

A 5-YEAR SURVEILLANCE OF SENSITIVITY OF PLASMODIUM FALCIPARUM TO PYRONARIDINE(PND)/SULFADOXINE(S)/ PYRIMETHAMINE (P) IN DIAOLUO REGION, HAINAN PROVINCE

1986～1987年在抗氯喹恶性疟流行区海南省吊罗山地区,以咯萘啶(咯)800mg、磺胺多辛(磺)1 000mg、乙胺嘧啶(乙)50mg,2d分服,作为常规治疗恶性疟,1988年起改用咯500mg、磺1 000mg、乙50mg的单剂。1986～1990五年间共治疗恶性疟435例。经体内法测定,当地恶性疟原虫对咯、磺、乙伍用均保持敏感,治愈率均为100％。

The pilot site of surveillance of sensitivity of P. falciparum to PND/S/P is locat- ed in Diaoluo area, Hainan Province, where P. falciparum is resistant to chloroquine. Acute fal- ciparum malaria was treated with PND/S/P as the only antimalarial, from 1986 to 1990 and a to- tal of 435 cases were treated. In vivo sensitivity of P. falciparum to PND/S/P were tested in some patients. It was demonstrated that the local P. falciparum remained sensitive to a single o- ral dosage of PAD 500mg/S 1000mg/P 50mg, with 100% cure rate.