231例脑囊虫病患者脑脊液中循环抗原检测分析

DETECTION OF CAg IN CSF OF 231 CEREBRAL CYSTICERCOSIS PATIENTS

本文报告应用抗猪囊尾蚴单克隆抗体(McAb)4F8-ELISA 对 231例脑囊虫病患者脑脊液中循环抗原(CAg)检测的结果。经与患者病史、临床分型和脑CT检查结果比较,发现脑脊液中CAg 与有无绦虫史无关。脑型合并皮下结节患者脑脊液中CAg 的阳性率明显高于单纯型脑囊虫病和皮下结节消失组的患者。CAg 检测的结果与囊尾蚴在脑部寄生的数量,病灶的新旧与部位等病理情况有关。表明 McAb(4F8)-ELISA 不仅可用于脑囊虫病的诊断,也有可能用于疗效评价。

The results of detection of circulating antigen(CAg) in cerebrospinal fluids(CSF) of 231 cerebral cysticercosis patients with McAb(4F8)-based ELISA were reported and compared with the case histories , clinical manifestations and CT scans. No relationship was found between CAg detected in CSF of these cases and history of taeniasis. However, the positive rate of CAg in cerebral cysticercosis patients with subcutaneous nodules was found significantly higher than those in cases with simple cerebral cysticercosis and in cases with subcutaneous nodules disappeared after anti-Cysticercus therapy before CSF collection. The results of CAg detection in CSF were related with the CT findings as well as the stage of the disease. It is thus indicated that MeAb(4F8)-based ELISA might be useful not only for diagnosis of neurocysticercosis, but also for the evaluation of efficacy of anti-Cysticercus therapy.