嗜酸性白细胞与幽门螺杆菌相关性胃炎

Eosinoohil Leucocyte and the HP-associated Gastritis

目的：观察慢性胃炎中嗜酸性白细胞（Eso）浸润与幽门螺杆菌（HP）感染的关系，探讨其引起慢性胃炎的可能机制。方法：胃镜活检材料456例，应用HE和美兰染色，光镜下分级、分型与计数，并进行统计学分析，结果：在456例胃粘膜标本中有Eso浸润者398例（87．28％），其中234例伴HP感染（58．80％）。且HP相关性胃炎的Eso浸润较非HP相关性胃炎要明显，Eso浸润与HP感染呈正相关（r＝0．8941，P＜0．001）。结论：在慢性胃炎中，Eso浸润是一种普遍现象。而HP与Eso在慢性胃炎的发生发展中起着协同作用。

Objective To observe the relation between the eosinophil leucocyte(Eso) infiltration and the helicobacter pylori(HP) infection in chronic gastritis, and to probe the mechanism about its occurrence. Methods 456 cases of Endoscopic specimens of stomach mucous membrane were stained with HE and methylene blue respectively for typing chronic gastritis, grading of HP Infection and counting the Eso under the light microscope. Statistical analysis was carried out. Results In 456 cases there were 398(87.28%) with Eso infiltration, in which 234(58. 80% ) had coexited with HP infection. The Eso infiltration in HP-associated gastritis was more obvious than that in non-HP-associated one, and the Eso infiltration was directly proportional to the HP infection(r =0. 8941, P< 0. 001 ). Conclusions: Eso infiltration is a general phenomenon in chronic gastritis. Eso infiltration and HP infection may be cooperative factors for pathogenesis of chronic gastritis.