X综合征患者血浆内皮素-1,降钙素基因相关肽水平变化及其临床意义

Levels of Plasma Endothelin, Calcitonin Gene-related Peptide and Their Clinical Significance in patients With Syndrome X

目的 探讨X综合征病人血浆内皮素-1(ET-1)和降钙素基因相关肽(CGRP)浓度变化与发病的关系.方法 测定34例X综合征病人ET-1和CGRP的血浆浓度,同时与29例无心肌缺血的对照组作比较分析.结果 ET-1:X综合征组血浆浓度(81.94±10.76ng/L)显著高于对照组(56.71±11.29ng/L,P<0.01).CGRP:X综合征组血浆浓度(50.74±13.26)ng/L显著低于对照组(64.89±11.58ng/L,P<0.01).ET-1/CGRP比值:X综合征组(1.58±0.49)显著高于对照组(0.91±0.33,P<0.01).结论 显著增高的ET-1水平和明显降低的CGRP浓度在X综合征发病中起重要作用.

Object To study the relation between the levels of ET-1 ,CGRP and syndrome X. Mothods Levels of ET-1 ,CGRP were measured in 34 patients with syndrome X and in 29 normal control subjects. Results In the syndrome X group,the levels of plasma ET-1 were higher than those of the normal control (P<0. 01) ,the levels of plasma CGRP were lower than the normal con-trol(P<0. 01) ,the ratio of ET-1/CGRP were higher than the normal control(P<0. 01). Conclusion The increase of plasma ET-1 and decrease of CGRP could play an active role in the disease process.