刺激的可逃避性和安定对大鼠应激导致镇痛的影响

The Effect of Escapbility and Diazepam on Footshock-induced Analgesia (FSIA) in Rats

本工作以改进的足底电击应激箱造成大鼠应激,用压脚法测痛,在应激后30min 内观察了54只大鼠的心理应激镇痛(SIA)现象。实验设计了可逃避与不可逃避2种刺激情境,并分别应用安定,以观察刺激的可逃避性和安定对 SIA 的影响。结果表明:足底电击导致了明显的 SIA;处于不可逃避情境中的大鼠产生了强于可逃避组的 SIA;安定对可逃避组 SIA 抑制作用显著。结果提示了对刺激情境的认知在 SIA 现象产生中的重要作用,并有助于痛觉心理学和生理心理学实验研究工作的开展和临床疼痛问题的解决。

In this paper,the phenomenon of stress-induced analgesia (SIA) was studied in 54 rats by means of paw-pressure technique,The pain threshold was measured 8 times within 30 min after footshock. There were two situations in the experiment:escapable and inescapable.Footshock could produce obvious SIA in rats.The analgesic effect from inescapable was stronger than that from escapable in the experiments. SIA could be reduced by diazepam.The effect of diazepam on SIA from eseapable was more obvious than that from inescapable.The result suggested that the cognitive process is important for producing SIA.The study is helpful to the pain psychology and physiopsychology and to resolving the problem of clinical pain.