原发性胃恶性淋巴瘤与幽门螺杆菌感染的相关性初探

Investigation on the Relationship Between Primary Gastric Malignant Lymphoma with Helicobacter pylori Infection

为了探讨原发性胃恶性淋巴瘤(RGML)与幽门螺杆菌(Hp)感染的相关性,本文收集39例 PGML了以及22例淋巴性胃炎、32例 Hp 无关疾病的胃粘膜行对照研究。结果:PGML 组 Hp 检出率87.18%,显著高于对照的63.64、53.13%(P<0.005)。粘膜相关淋巴样组织(MALT)来源的淋巴瘤占92.31%。Hp 检出率达86.11%,瘤周慢性活动性胃炎及淋巴滤泡检出率分别为84.62、56.41%,且炎症活动程度与 Hp 分布密度相关。组织学研究提示胃 B 细胞 MALT 淋巴瘤与 Hp 感染相关。

In order to investigate the relationship between primary gastric malignant lymphoma (PGML)Helicobacter pylori(Hp)infection,the gastric mucosa of 39 cases of PGML,22 cases of lymphocytic gastritis and 32cases of Hp-unrelated diseases was collected in this case-control study. Results:The Hp-detecting rate of PGML was 87.18% which was significantly higher than that of the control groups which were 63.64 and 53.13% respectively(P<0.005).MALT(mucosa-associated lymphoid tissue)type accounted for 92.31% of PGML cases with Hp-detecting rate of 86.11.chronic active gastritis and lymphoid follicles were detected in the surrounding tissue in 84.62% and 56.41 cases of PGML respectively.Moreover,the degree of gastritis was correlated to the degree of Hp colonization histological there is a good relationship between B cell gastric MACT lymphoma and Hp infection.