高原部队人群幽门螺杆菌感染的流行病学调查

EpidemiOlOgical Study On HelicObacter PylOri InfectiOn Of POpulatipn Of Army Team in High Altitude

目的了解Hp在高原部队人群中感染状态及与上消化道疾病的关系。方法对驻青藏高原(海拔2800-5231公尺)某部官兵517人进行普查,年龄18～40岁。采用冒镜普查和^(14)C-尿素呼吸试验方法,接受胃镜普查的受检者均在胃窦部取活检2块,分别行Hp快速尿素酶试验和病理检查。结果高海拔地区部队人群Hp感染率较低海拔地区为高,入伍仅1月的新兵,Hp感染率为38.18％,而另两组人群长期生活在高原不同海拔高度至少1年以上,Hp感染率达52.42％和62.32％。新兵组与其它两组相比具有显著性差异(P<0.05和p<0.01)。结论不同海拔高度Hp感染率不同,高海拔地区部队人群Hp感染率较低海拔地区为高,高原自然环境特点和缺氧可能是导致Hp在胃粘膜的定植并引起Hp感染率增加的重要素因之一。

AIM The aim of this study is to inerestigate relationship of Upper gastrointestinal diseases with Helicobacter pylori infection in the population of army team in high altitude. METHODS The methods of gastroendoscopy combined with Hp rapid urease test and capsule-based (14)~C-urea breath test for the detection of Hp were used. RESULTS The positive rates of Hp infection were higher in the group of army team at above sea level than that at lower one. Hp infective rates were 38.18％ in the group of new army men who joined the army only for one month, 52.42％ in the group at 2800 metres above sea level, and 62.32％ in the group at 4000-5300 metres above sea level. There is significant difference in new army men group compared with other two groups(p<0.05 and p<0.01). CONCLUSION We consider that the increase of Hp infective rate may be caused by the environment and short of oxygen at high altitude.