实验脾虚证组织中胃泌素及生长抑素含量变化及其意义

The Experimental Study on the Relationship between Gastrin and Somatostatin in Tissue and Spleen Asthenia Syndrome

目的:探讨胃泌素(Gas)、生长抑素(SST)与脾虚证发生的关系。方法:观察实验脾虚证发生过程中组织 Gas、SST 含量的变化,并用四君子汤反证。结果:脾虚时组织中 Gas 含量低下,SST 含量增高。经四君子汤预防和治疗的脾虚大鼠,Gas、SST 水平紊乱的状态得到明显的改善,明显优于脾虚自然恢复大鼠。结论:结果初步表明组织中 Gas、SST 水平紊乱是导致脾失健运的主要原因之一。

To explore the relationship between gastrointestinal hormones and pathogene- sis of spleen asthenia syndrome.Methods.The variations of Gas and SST in tissue were measured by RIA,and Sijunzi decoction(SIJD)was chosen for confirmation.Results:The level of Gas sig- nificantly decreased and SST markedly increased in spleen asthenia syndrome, which was im- proved and even better than spontaneous recovery group after prevention and therapy with SIJD. Conclusions:The study confirmed that disorder of Gas and SST would lead to Pi Shi Jian Yun.