期刊文献+

类风湿性关节炎的药物治疗进展 被引量:1

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摘要 1 非甾类抗炎药(Nonsteroidal Anti-Intlammatary Drugs,NSAIDs) NSAIDs问世以来,应用十分广泛。品类日益增多,虽然其化学结构各不同,但均具有以下特点: 1.1 这类药物小剂量主要抑制前列腺素(PG)合成而起到镇痛作用;大剂量还可能降低溶酶体活性、减少酶的释放及减少巨噬细胞生成过氧化物等而发挥抗炎作用。因此在RA治疗中剂量有增大的倾向。这类药具有起效快,服药数日内即可发生作用。
机构地区 汕大医学院内科
出处 《中国康复医学杂志》 CAS CSCD 1993年第3期138-140,共3页 Chinese Journal of Rehabilitation Medicine
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参考文献1

  • 1A. J. Taggart. Sulphasalazine in arthritis — an old drug rediscovered[J] 1987,Clinical Rheumatology(3):378~383

同被引文献15

  • 1Wylie B,Appelboom T,et al.A comparative study of tenidap,a cytokine modulating anti-rheumatic drug,and diclofenac in rheumatoid arthritis:24-week analysis of a 1-year clinical trial. British Journal of Rheumatology . 1995
  • 2Mcniff f P,Robinson RP,et al.Reduction of intracellular pH by tenidap involvement of cellular anion transporters in the pH change. Biochemical Pharmacology . 1995
  • 3Fujii A,Matsumoto H,et al.++</sup>and inhibits Ca<sup>++</sup>influx in cultured human gihgival fibroblasts&amp;sid=Journal of Pharmacology and Experimental Therapeutics&amp;aufirst=Fujii A');&#xA; ">Tenidap,an anti-inflammatory agent,discharges intracellular Ca<sup>++</sup>and inhibits Ca<sup>++</sup>influx in cultured human gihgival fibroblasts. Journal of Pharmacology and Experimental Therapeutics . 1995
  • 4Sipe JP,Bartle LM,et al.Modification of proinflammatory cytokine production by the antirheumatic agents tenidap and naproxen:a possible corelate with clinical acute phase response. J Immunol . 1994
  • 5Matsushita I,Matsuno H,et al.Immunomodulating effects of the new anti-rheumatic drug tenidap on collagen induced arthritis. International Journal of Immunopharmacology . 1995
  • 6Madhok R.Tenidap. The Lancet . 1995
  • 7Blackburn WD,Loose LD,et al.Tenidap. Arthritis and Rheumatism . 1991
  • 8Kirby DS,Loose LD,et al.Tenidap versus naproxen in the treatment of rheumatoid arthritis. Arthritis and Rheumatism . 1993
  • 9Laliberte R,Crilly A,et al.Tenidap modulates cytoplasmic pH and inhibits anion transport in-vitro. J Immunol . 1994
  • 10Beedveld F.Tenidap:a novel cytokine-modulating antirheumatic drug for the treatment of theumatoid arthritis. Scandinavian Journal of Rheumatology . 1994

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