利维爱预防卵巢早衰患者骨量丢失作用的探讨

Effect of Livial prevention bone loss in patients with premature ovarian failure

本文通过给１２例卵巢早衰患者利维爱（Ｌｉｖｉａｌ）用药２个月，并于给药前后分别测定空腹尿钙与肌酐（Ｃａ／Ｃｒ）、羟脯氨酸与肌酐（ＯＨＰｒ／Ｃｒ）比值以及血清碱性磷酸酶（ＡＫＰ）、雌二醇（Ｅ２）、骨钙素（ＢＧＰ）、降钙素（ＣＴ）和白细胞介素－６（ＩＬ－６）的水平，以探讨Ｌｉｖｉａｌ防止卵巢早衰患者骨量丢失的作用机制。结果显示：Ｌｉｖｉａｌ给药后空腹尿Ｃａ／Ｃｒ、ＯＨＰｒ／Ｃｒ比值明显下降（Ｐ＜０．０１，Ｐ＜０．０２）；血ＡＫＰ、ＢＧＰ的水平无明显变化；ＣＴ的水平显著升高（Ｐ＜０．０５），ＩＬ－６的水平显著下降（Ｐ＜０．０２）。提示：Ｌｉｖｉａｌ能有效地改善年轻的卵巢早衰患者的骨代谢状况，防止其骨量的丢失，刺激ＣＴ的分泌和抑制ＩＬ－６的产生可能是Ｌｉｖｉａｌ改善卵巢早衰患者骨代谢状况的重要作用机制之一。

In order to understand the mechanisms of livial in prevetion of bone loss in patients with premeture ovarin failure.12 cases pstients were treated with livial for two months.Then fasting urinary calcium creatinine ratio(Ca/Cr)、hydroxyproline creatinine natio(OHPr/Cr)、Serum akaline phosphotase(AKP)、estradio(E2)、Calcitonin(CT)、bone gla protein (BGP) and interleukin 6(IL 6) were determined for these patients before and after treatment.The results showed that Ca/Cr.OHP/Cr ratios fell significantly( P <0 01, P <0 02),but serum AKP and BGP remained unchanged.In addition,it was shown that the level of CT increased ( P <0 5)and IL 6deredsed ( P <0.01) significantly in these patients.It is concluded that the bone metabolism was improved effectively in patients with premature ovarin failure after livial treatment.It is probably one of the mechanisms by which livial improves bone metabolism increasing the seurm level of CT and decreasing it of IL 6.