细胞因子在老年骨丢失中的作用

Role of cytokines in pathogenesis of bone loss in the elderly

目的 探索细胞因子在老年骨丢失发病过程中的作用。 方法 取新鲜性老年股骨颈骨折的股骨头和正常青年股骨头，进行骨矿含量、白细胞介素６、肿瘤坏死因子检测。 结果 老年组股骨头骨矿含量明显低于青年组（ Ｐ＜ ００１），老年组的骨匀浆白细胞介素６含量有升高趋势，但与青年组无统计差异（ Ｐ＞ ００５），老年组肿瘤坏死因子含量显著高于青年组（ Ｐ＜ ００１），肿瘤坏死因子与骨矿含量呈显著的负相关（ｒ＝ － ０７４３， Ｐ ＜ ０００１）。

Objective\ To explore the role of cytokines in pathogenesis of bone loss in the elderly.Methods Cancellous bone samples of femoral head from 12 aged patients with fresh femoral neck fracture and 6 normal young adults were obtained.Bone density of the samples was assessed by bone mineral content.Interleukin\|6(IL\|6),tumor necrosis factor\|α(TNF α) in the homogenates of the samples were measured by enzyme\|linked immunosorbent assay. Results \ The bone density in aged group is significantly lower than that in young group( P <0 01).IL\|6 in aged group have a tendency to rise;however,there is no statistical difference between the elder and young groups( P >0 05).In contrast,TNF\|α in elder group is significantly higher than that in young group( P <0 01).There is a remarkable negative correlation between the bone mineral content and TNF\|α( r=-0 743,P<0 001). Conclusion\ TNF\|α plays a critical role in the pathogenesis of osteoporosis.\;