肠炎性病变患者骨密度测量的临床意义

Clinical significance of bone mineral density measurement in inflammatory bowel diseasesClinical significance of bone mineral density measurement in inflammatory bowel diseases

目的 研究肠炎性病变时骨密度的变化及其临床意义。方法 对３０ 例肠炎性疾病者及３０例健康者，用双能Ｘ 线吸收法（ＤＸＡ）做了全身、腰椎２～４、股骨颈的骨密度测量和肌肉组织以及体脂肪量测量。并作了比较性研究。结果 肠炎性疾病易并发骨质疏松。骨质疏松似有选择性。股骨颈骨量减少较腰椎者明显，故前者宜作为首选受检部位。全身肌肉组织量与全身骨密度正相关。肌肉量测量可反映骨量增减。结论 肠炎性疾病可并发骨质疏松。为预测、预防骨质疏松，密切观察股骨颈骨密度和肌肉量的变化是必要的。

Objective\ To study bone meneral density (BMD) changes and its clinical significance in patients with inflammatory bowel diseases (IBD). Methods \ Thirty IBD patients and 30 healthy people were studied.Bone mineral density values(g/cm 2) were measured by Lunar DPX-L dual energy x ray absorptiometry at the whole body,lumbar spine (L2-L4) and femoral neck.Lean tissue mass(LTM)and amount of fat of the whole body were measured.The relationship between measured data and clinical materials was analysed. Results \ The IBD patients had an increased prevalence of osteoporosis,which seemed to have selectivity.The prevalence of reduced BMD in femoral neck was greater than that in lumbar spine;therefore,the former should be chosen first for bone measurement.LTM was positively correlated with the whole body BMD;measurement of LTM could reflect the change of BMD.Conclusion IBD can result in osteoporosis.In order to predict and prevent the osteoporosis,it is necessary to closely observe the change of BMD in femoral neck and of lean tissue mass.