损伤血管中血管紧张素原基因的表达

Expression of angiotensinogen gene in injury vessels

目的测定损伤血管中血管紧张素原基因的表述状况，进一步阐明局部肾素－血管紧张系统（RAS）在损伤诱导的VSMC增殖中的作用。方法在以球囊内皮剥脱法建立血管损伤模型的基础上，用斑点杂交法测定损伤血管中血管紧张素原mRNA的表述状况。结果损伤血管组织中血管紧张素原mRNA的表达增高。结论局部RAS在损伤诱导的VSMC增殖中起重要作用。

Purpose The expression of angiotensionogen(ANGT) gene mRNA was obserbed in order to further clarify thefunction that the local renin-angiotensin system(RAS) played in the vascular smooth muscle cell (VSMC) overgrowthinduced by injurying. Methods The expression of angiotensinogen gene in injury vessels was detected by dot blot. Re-sults The mRNA of angiotensinogen in injury vessels was higher than that in the norrnal vesse1s. ConcIusion LocalRAS played an imortant role in the VSMC overgrowth induced by injuring.