儿童病毒性心肌炎血清学指标研究

Establishing a serum method for diagnosis of viral myocarditis in children

目的:建立实验室诊断儿童病毒性心肌炎,疑似心肌炎的指标。方法:动力学连续监测法测CKMB、CK。结果:健康儿童、病毒性心肌炎患儿,疑似心肌炎患者CKMB分别为:10.25±7.88,42.98±22.49,22.48±14.68;CK分别为92.18±45.1,268.15±203.1,121.24±67.8。病毒性心肌炎中85.2％(KMB增高,51.9％CK增高;疑似心肌炎61.8％CKMB增高,32.4％CK增高。患儿64％一年内不复发,36％一年内复发。结论:CKMB、CK的测定用于病毒性心肌炎、疑似心肌炎早期诊断,动态观察对临床治疗,预后更有意义。CKMU优于CK。

Objective To establish a lab method to diagnose Viral myocarditis in children Methods: Kinetic rate assay method was used to determine CKMB and CK,Results: The ranges of CKMB of the healthy children, children with viral mycoarditis and suspicious myocarditis were 10. 25 ± 7. 88,42. 98± 22.49, 22.48 ± 14. 68; and the ranges of CK were 92. 18 ± 45. 1,268. 15± 203. 1, 121.24±67. 8 respectively. In children with viral myocarditis, 85. 2% CKMB was increased. 51.9% CK was increased. In children with suspicious myocarditis, 61. 8% CKMB became higher, 32. 4% CK became higher. 64% of the sick children wouldn't get a relapse in one year,but 36% would have.Conclusion: CKMB and CK could be applied for early diagnosis of viral myocarditis and suspicious myocarditis. Dynamic observation plays an importan role in clinical treatment.CKMB is more sensitive than CK.