摘要
目的 确定结直肠癌患者有效的预后参数及最佳预后指标。方法 对８３ 例不同分期的结直肠癌肿瘤转移抑制基因Ｎｍ２３ 的表达、巨噬细胞的浸润、人类白细胞抗原ＨＬＡＤＲ 的表达、肿瘤的浸润深度、Ｄｕｋｅｓ分期及其它临床指标进行单因素和多因素ＣＯＸ回归分析。结果 单因素分析得出的有关预后因素中，经多因素分析只有Ｄｕｋｅｓ 分期一项进入ＣＯＸ 模型。结论 Ｄｕｋｅｓ 分期是结直肠癌患者最重要和最佳的预后指标。
Objective To determine the effective prognostic parameter and the best prognostic index . Methods The prognostic relevance of clinical and pathological variables were evaluatedin 83 patients with histologically proved colorectalcarcinoma,(includingthe expression of Nm23 , HLA DR,the infiltration of macrophage) by the multivariate analysis of COXregression . Results Dukes’staging wasan only parameterto enterthe COXmodel.Conclusion The Dukes’ stagingisthe mostimportant,reliable and best varible factor in predicting the clinical outcome of colorectalcancer.
