胃癌患者胃窦粘膜TNF-α含量的检测及临床意义

The relationship between antrai mucosal tumor necrosis factor-α concentration and gastric cancer

目的:探讨胃癌患者胃窦粘膜TNF-α含量与胃癌间关系。方法:应用放射免疫法(RIA)检查92例接受胃镜检查的患者胃窦粘膜TNF-α含量,比较胃癌与非癌性胃十二指肠患者之间的差异。其中胃粘膜正常者5例,单纯性慢性胃炎(CG)30例。十二指肠球部溃疡(DU)35例,胃癌(GCa)22例。结果:GCa患者胃窦粘膜TNF-α明显高于CG组及组织正常胃粘膜(p<0.05),但与DU组比较无明显差别(p>0.05)。结论:TNF-α含量在胃癌患者胃窦部增高,但与DU组比较无明显差别。提示TNF-α与胃癌发生、发展有关,但胃粘膜TNF-α并非胃癌的特异性标志物。

To investigate the relationship between antral mucosal tumor necrosis factor-α concentration and gastric cancer. Method: The gastric mucosal biopsies were obtained from 92 individuals whose endoscopic and pathologic diagnoses were normal (n=5) gastric cancer (n=22), chronic gastritis (n=30), duodenal bulbar ulcer (n=35), level of TNF-α in gastric biogsy homogenate supernatant fluid were measured by radioimmunoassay. Results: The mucosal levels of TNF-α were significantly higher in gastric cancer patients than those of normal group ancl CG group (p<0.05), but there were no statistical differences between GCa and DU group (p>0.05). Conclusion: This study inducates that a strong correlation exists between mucosal TNF-α level and gastric cancer, TNF-α may play a part the pathogenesis of gastric cancer. The TNF-α level of GCa group was not significantly higher than that of DU group, which shows antral mucosal TNF-α level can not be a potential diagnostic marker in patients with gastric cancer.