实验性胃肠道功能紊乱症胃泌素及生长抑素变化意义

Relationship between Gastrin、Somatostatin and Functional Distrurbance of Gastrointestinal Tract

目的:探讨胃泌素(Gas)、生长抑素(SST)与胃肠道功能紊乱发生的关系。方法:用RTA方法检测胃肠道功能紊乱模型大鼠体液及组织中Gas、SST含量的变化,并用四君子汤反证。结果:与正常对照相比,胃肠道功能紊乱时血浆、胃液、肠液、胃窦、十二指肠、下丘脑组织中Gas含量低下(分别为109.46±40.88ng/L,30.78±6.81ng/L,96.58±14.36ng/L,232.61±53.88ng/g,22.47±3.02ng/g,68.09±13.40ng/g,P均<0.05),SST含量增高(分别为32.56±7.91ng/L,29.21±4.58ng/L,25.74±4.16ng/L,367.15±42.30ng/g,47.31±10.97ng/g,66.76±6.55ng/g,P均<0.05)。经四君子汤预防和治疗的胃肠道功能紊乱模型大鼠,Gas和SST水平均得到明显的改善,明显优于自然恢复大鼠(P<0.05)。结论体液及组织中Gas、SST水平紊乱是导致胃肠道功能紊乱发生的主要因素之一。

To explore the relationship between gastrointestinal hormones and pathogenesis of functional disturbance of gastrointestinal tract. Methods The variations of Gas、SST in body fluid and tissues were measured by RIA. Sijunzi decoction(SIJD) was chosen for confirmation. Results The level of Gas in plasma, gastric juice, intestinal juice, gastric antrum, je junum and hypothalamus of functional disturbance of gastriointestinal tract was significantly less(109.46±40.88ng/L, 30.78±6.81ng/L, 96.58±14.36ng/L, 232.61±53.88ng/g, 22.47±3.02ng/g, 68.09±13.40ng/g, P均<0.05) and SST markedly more(32.56±7.91ng/L, 29.21±4.58ng/L, 25.74±4.16ng/L, 367.15±42.30ng/g, 47.31±10.97ng/g, 66.76±6.55ng/g, P均<0.05)than the contrast group, which was improved and even better than spontaneous recovery group after prevention and therapy with SIJD(P均<0.05). Conclusion The study confirmed that disorder of Gas and SST would lead to functional disturbance of gastrointestinal tract.