慢性阻塞性肺病患者免疫状态的研究

STUDY OF IMMUNE STATUS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASES

采用CD系列抗人T淋巴细胞单克隆抗体,ABC免疫组化技术测定83例老慢支,26例慢阻肺患者外周血T淋巴细胞亚群,并与13例老年前期健康组及17例老年健康组对照。结果显示CD_8阳性细胞百分率老年健康组高于老年前期健康组,老慢支组、慢阻肺组高于老年健康组。CD_4/CD_8阳性细胞比例老年健康组低于老年前期健康组,老慢支及慢阻肺组均低于老年健康组。同时检测IL-2、NKC活性,结果显示NKC活性老年健康组明显高于老年前期健康组,两疾病组低于老年健康组,提示健康老人NKC代偿性增强。IL-2活性各组均低于正常值(57.04±4.7)。淋巴细胞转化率呈明显的增龄性变化,年龄越大越低,老慢支组较健康组低,慢阻肺组最低。本文研究资料再次证实健康老人,慢支及慢阻肺患者,体内免疫细胞功能低下及功能调节异常,为此对老慢支防治工作方面,应全面分析机体免疫状态、致病菌和抗生素三者之间的关系,对免疫功能低下和免疫调节异常的治疗应有足够的重视。

The T lymphocyte subsets, the natural killer cells (NKC), the interleukin-2 (IL-2) and the lymphocyte transformation rate were studied with immunological methods, The studied groups were consisted of (A) 83 patients with senile chronic bronchitis (SCB), (B) 26 patients with chronic obstructive pulmanary disease (COPD), (C) 13 normal adults and (D) 17 healthy elderly. The results showed that:① as for CD8+%, D>C, and D< A,B; ② as for CD4+/CD8+, D<C, and D>A,B; ③ as for NKC, D>C, and D>A,B; ④ as for IL-2, A,B,C,D< normal range (57.04±4.7);⑤ as for lymphocyte transformation rate, D< C, and D > A >B. Conclusively, this investigation elucidated that the cellular immunity was abnormal in healthy elderly (D), COPD patients (B) and SCB patients (A), Therefore, more attention should be paid to the relation among immunity, pathogenic bacteria and antibiotics in treating the diseases as mentioned above.