摘要
报道１５８例骨矿含量低于正常值１个标准差（Ｓ）的青壮年（２０～４０岁）甲亢患者的治疗结果。在用１３１碘或抗甲状腺药或手术治疗的同时，使用维生素Ｄ３、维生素Ａ＋Ｄ、葡萄糖酸钙片、肾骨胶丸、饮食含钙丰富的食品等进行综合治疗。结果骨面密度有明显提高，男患者由０．５８４±０．１１～０．６０２±０．１２ｇ／ｃｍ２提高到０．６９８±０．１１～０．７０４±０．１３ｇ／ｃｍ２；女患者由０．５３７±０．０９～０．５６０±０．０９ｇ／ｃｍ２提高到０．６６２±０．１０～０．６７８±０．１１ｇ／ｃｍ２，其差别非常显著（Ｐ＜０．０１）。骨矿恢复正常的百分率：单纯１３１碘治疗组，男３７．５％（６／１６），女３５．７／（１０／２８）；１３１碘加综合治疗组，男６６．６％（１２／１８），女７３％（１９／２６）；抗甲状腺药加综合治疗组，男８１．２％（１３／１６），女８０．５％（２９／３６）；手术加综合治疗组，男７５％（６／８），女７０％（７／１０）。说明青壮年甲亢患者的骨矿物质丢失是可逆的。经过治疗，随着甲亢的治愈，骨矿含量大部分都得到恢复。
This paper reports the results of treatment in 158 patients with hyperthyroidism bedween the ages of 20 and 40 and with bone mineral content under normal value. These patients were treated with 131I or antihyroid drug or surgery plus comprehensive therapy which consists of vitamin D3 , vitamin A+D,calcium gluconate ,Caps. Kidney Bone and food rich in calcium. The results showed that the bone mineral density in male patients increased from 0. 584 ± 0. 11～0. 602 ± 0. 12g/cm2 to 0. 698± 0. 11 ～0. 704 ±0. 13g/cm2 and in female patients from 0. 537 ± 0. 09 ～ 0. 560 ± 0. 09g/cm2 to 0. 662 ± 0. 10～ 0. 678 ±0. 11g/cm2, the differences pre-therapy and post-therapy being statistically significant (P< 0. 01). After treatment the bone mineral density returned to normal value in 37. 5 % (6/16)and 35. 7% (10/28) of male and female patients respectively treated with 131I alone, in 66. 6 % ( 12/18)and 73% (19/26) male and female patients fespectively treated with 131I plus comprehensive therapy in, 81 . 2% ( 13/16 )and 80. 5 % (29/36) of male and female patients respectively treated with antithroid drug plus comprehensive therapy,and in 75% (6/8)and 70% (7/10) of male and female patients respectively treated with surgery plus comprehensive therapy. These results suggest that bone mineral content loss in patients with hyperthyroidism aged 20 to 40 years is reversible. After the patients with hyperthyroidism were cured,the amount of bone mineral in majority of patients could return to normal range.
出处
《中国骨质疏松杂志》
CAS
CSCD
1996年第1期9-11,共3页
Chinese Journal of Osteoporosis
