合肥地区脑力劳动妇女绝经前后骨密度和垂体－性腺功能状态及其关系的研究

Bone mineral density and pituitary-gonadal function and their interrelation in menopausal mental working women in Hefei district

选取合肥女性脑力劳动者５２６例，用ＳＰＡⅣ型骨密度仪检测桡骨骨密度及放射免疫法测定性激素。发现骨量峰值在４０～４４岁，较一般报告迟５～１０年。接着，围绝经期线密度和面密度分别以１１％和７．１％的年丢失率急剧跌落。以后，以１％左右作较慢而进行性降落。激素测定的结果反映绝经期垂体促性腺功能呈持续高反应状态；卵巢功能则处于进行性衰减过程。围绝经期功能反应极度活跃，而绝经≥１０年见有缓解。相关分析证实骨密度与ＦＳＨ、ＬＨ、Ｅ２、Ｔ、ＰＲＬ相关，肯定了骨密度与垂体－性腺功能状态的线性关系。提示防治监测标准应包括诸相关激素和ＦＳＨ／ＬＨ指标。

The authors made an analysiss of the data on 526 cases of menopausal mental working women in Hefei district. As a result,we found the bone mineral density(BM)peak at the age of 40-44. It is also shown that there is high response of pituitary function while the ovarian function decreases with age. By means of correlative regression analysis and multiple correlative regression analysis, we found close correlation between BMD and folli cle-stimulating hormone, luteinising hormone ,estradiol ,prolactin. It is suggested that the standards of prevention.treatment and monitoring should include the above indexes, and age periods for differential prevention and treat ment in clinical study are proposed.