摘要
幽门螺杆菌(Helicobacter pylori, HP)根除后重感染率在发达国家与发展中国家的报道差异很大。我们对85例HP根除后患者进行1～2年随访,定期于停药后3,6,12,18和24个月进行^(14)C-尿素呼吸试验检查。在停药后12、24个月或当呼吸试验呈阳性结果时分别行胃镜检查.胃镜下取胃窦及胃体粘膜行尿素酶、组织学及培养等检测HP,并观察溃疡复发情况。结果:①发现HP阳转在停药3个月有6例(7.1％)、6个月有1例(1.2％)及6个月以后无1例;②经随机引物DNA多态指模技术鉴定,停药3个月感染之HP菌株分别与该患者治疗前HP菌株具有相同的电泳图谱,表明停药早期检出的HP感染实为复发而非再感染;③本组病人中有20例患者在治疗前有1～7次的溃疡出血史,根除治疗后在随访1～2年中无1例再发出血。结论:中国人HP根除后年重感染率低于2％,与发达国家报道相仿。
Eighty five cases of patients with eradication of helicobacter pylori (HP) were researched by ^(14)C-urase breath test at the 3rd, 6th,12th, 18th ad 24th month after the ending of treatment. Endoscopical examination was performed at the 12th, 24th month after treatment or performed whenever the ^(14)C-urase breath test was positive. The results showed that the infection was found again in the 6 patients(7.1％) at 3rd month and 1 patient(1.2％) at 6th month. No positive cases was seen after that time. Recurrence of HP was identified by means of a random amplified polymorphic DNA-PCR(RAPD-PCR) by compared with the strains got before three month ago. In 4 patients,HP showed the same electrophoresis profile. No ulcerous bleeding appeared after 1-2 years follow-up after treatment of HP. It is suggested that reinfection in Chinese people was less than 2％ after eradication of HP.
