摘要
对83例幽门螺杆菌(HP)阳性的青年志愿者采用小量多次的改良“三联”方案进行了治疗。其中十二指肠溃疡(DU)9例,麋烂性胃炎10例,其余为慢性红斑渗出性胃炎,所有患者均有消化不良症状,治疗方案:三钾二枸椽酸铋107.7mg,四环素250mg和甲硝唑200mg,每日5次,10天一疗程。^(14)C-尿素呼吸试验(UBT)评价HP根除效果,DU者重复胃镜检查。随访62例,均进行UBT试验。结果:UBT阴性51例:DU者溃疡均已愈合且HP阴性,HP根除率为86.4％。此外,89％的病人症状改善或消失。结果显示这种小剂量多次数的“三联”方案疗效确切,副作用少而轻微,类似方案值得临床上推广应用。
To evaluate the efficacy of Gastrostat,a modified bismuth-based triple regimen,to eradicate H. pylori infection,eighty three young male volunteers were enrolled in the study. Most of them complained of dyspeptic symptoms. Nine had active duodenal ulcer, 10 had erosive gastritis and the remainings sudderedfrin chronic active gastritis. H. pylori was determined by rapid urease test,H, pylori culture and Warthin-Starry silver staining. All patients were H. pylori positive. The Gastrostat was given orally of TDB 107.7mg,metronidazole 200mg and tetracycline 250mg,five times a day with the course of 10 days. ^(14)C-urea breath test (UBT) was used to evaluate H. pylori eradication. Sixty-two patients were followed up. All the patients received ^(14)C-UBT and those with duodenal ulcer were also re-examined endoscopically. Fifty-one were negative for UBT.Those with endoscopy had no ulcer in the duodenum and H. pylori in the antrum and body. The eradication rate of H. pylori was 86.4％. Symptoms were also improved or disappeared in 89％ ofthe patients. Most of the side effects was slight and mild, which were all disappeared in continuing administration or after the regimen. The results show that Gastrostat is an exactly effective regimen to treat H. pylori positive gastropathy with much less side effects than that of the standard methods, especially for those with duodenal ulcer. It is worthwhile to recommend for Gastrostat, or the similar regimen,to be used in the clinical.
