肝炎、肝硬变和肝癌大鼠血中10种微量元素的变化

Changes of ten kinds of trace elements of blood in rats with hepatitis and cirrhosis and hepato cellular carcinoma

本文系列观察了DAB诱发肝炎、肝硬变和肝癌大鼠血中10种微量元素变化及其变化规律。给予Wistar大鼠喂养DAB饲料26周。在实验第8周(肝炎期)、18周(肝硬变期)和26周(肝癌期)分别检测6只肝炎、肝硬变和肝癌大鼠血中10种微量元素。结果显示:肝炎时仅Mn低于正常组(P<0.005);肝硬变时Mn、Ba、Fe、Si、Zn和Se均显著低于正常组(P<0.05～0.001),Cu显著高于正常组(P<0.001);肝癌时Mn、Ba、Fe、Si、Zn、Se和Mo均显著低于正常组(P<0.05～0.001),Cu和Cr显著高于正常组(P<0.001)。结果表明:1.肝病越重,微量元素变化越明显;2.Se、Zn、Mn、Si、Fe、Mo和Ba可能对肝硬变和肝癌有预防作用。

The changes of 10 kinds of trace elements in blood were serially observed by ICP method in rats with hepatitis cirrhosis and hepato cellular carcinoma. Rats were fed with DABfood for 26 weeks Ten 10 kinds of trace elements in blool were detected by ICP method in rats at the stage of hepatitis (8th week) and cirrhosis (18th week) and hepatocarcinoma (26th week) respectively. The results showed that at the stage of hepatitis cellular Mn lerel in experimental group was significantly lower than that in contral group (p<0.05). At the stage of cirrhosis lerels of Mn,Ba,Fe,Si,Zn and Se were lower (P<0.05～0.001) and that of Cu was higher (P<0.001) in experimental group than that in contiol group. At the stage of carcinoma Mn. Ba,Fe,Si,Zn,Se and Mo levels were lower (P<0.05～0.001) and the Cu and Cr were higher (P<0.001) in experimental group than that in contiol group, results indicated that the more severe hepatic disease the more obvious alterations of the trace elements, and the trace elements Se,Zn,Mn,Si,Fe,Mo and Ba may be beneficial to prevention of liver cirrhosis and hepato cellnlar carcinoma.