摘要
本文调查了155例十二指肠溃疡旁粘膜的组织病理学变化,并与对照组相比较。结果显示:溃疡旁组织炎症、胃化生和Hp检出率分别为69.7％、75.5％和24.5％,显著高于对照组的18.8％、10.4％和4.2％(P<0.01)。Hp在胃化生组织中的检出率为32.8％,81例不伴胃化生的粘膜中均未检出Hp(P<0.01)。透射电镜观察胃化生有其特征性改变。提示胃化生可能是溃疡形成的基础,Hp在化生区定植并非是产生溃疡的唯一直接因素,还可能通过其他复杂环节间接起作用。
The paraulceratiue mucosa samples were edamined Pistopathologically for the pathological changes' in 155 patients with duodenal ulcer (DU),The patients with out ulcer were served as control. The results showed the prevalence of inflammation in para-ulceratic mucosa, gastric metaplasia (GM) and Helicobacter pylori infection in the duodenum were 69.7％, 75.5％ and 24.5％, respectively, which were higher than those of the control (18.8％, 10.4％ and 4.2％, respectively) (P<0.01). Hp was found in the mucosa of 32.8％ paticnts with GM and not in 81 cases with out GM (P<0.01). TEM showed there was a characteristic change in the mucosa with GM. It is suggested that GM may be the basis of ulcerogenesis. Residence of Hp in the GM area may be not the sole direct cause in DU development,and some complex episodes may indirectly work.
