摘要
东亚钳蝎毒素是东亚钳蝎毒腺细胞分泌的一种具有多种生物活性的小分子多肽类物质。对其药理、毒理研究发现蝎毒素结构复杂,稳定性强。在此基础上,我们应用体外细胞培养的方法,已证实蝎毒素对大肠癌细胞具有显著的抑杀作用。为进一步探讨蝎毒素抑杀肿瘤细胞的机理,我们用东亚钳蝎毒素灌胃治疗大鼠实验性大肠癌,并详细观察了用药前后大肠肿瘤细胞超微结构的变化,结果表明:(1)使用蝎毒后大肠肿瘤体积明显变小,小鼠荷瘤率明显降低。(2)蝎毒对肿瘤细胞膜、细胞核、细胞器均具有直接破坏作用,且能直接影响肿瘤细胞的代谢及核酸活性。
East-Asian scorpion venom, secreted from the glandular epithelium of East-Asian scorpion, is a kind of lower-molecular-weight polypeptide, that has many biological activities. It was found that scorpion venom had notable inhibition of colorectal cancer cells by in vitro cell culture. To further explore the mechanism of the inhibition of cancer cells, ultrastuctural changes of cancer cell were studied in experimental colorectal carcinoma inhibted with scorpion venom. It is concluded that scorpion venom can cancer cellsdirectly, which make the tumor decrease in volume
