硝酸甘油抗血小板聚集及其耐药性研究

The Antiplatelet Aggregative Effects and Tolerance at Patelet Level of Nitroglycern in Patients with Coronary Atery Disease

12例冠心病心绞痛及心肌梗塞患者持续24小时静脉滴入小剂量的硝酸甘油,观察用药前后不同的时间血小板聚集功能、血压、心率及临床效应.结果显示:静脉滴入硝酸某油半小时后检查发现患者体内血小板聚集被显著地抑制,此抑制效应持续20小时,24小时后硝酸甘油抗血小板聚集效应消失.用药前后心率及血压无显著性改变.此结果说明静脉滴入小剂量的硝酸甘油对冠心病患者体内的血小板聚集功能具有显著性抑制作用,但连续用药24小时此抑制效应消失,即抗血小板聚集作用产生了耐药.

To investigate antiplatelet aggregative effects and tolerance at platelet level of nitroglyc-ern(NTG),12 patients with unstable angina and acute myocardial infarction were given intravenous NTG continueously at 20 μg/min for 24 hours. Peripheril venous blood were taken at different infusion hours to study the effects of platelet aggregation. Platelet aggregative effects were inhibited markedly at half hour and lasted for 20 hours after administration of NTG. The platelet aggregative level returned to basal line after continuing 24 hours infusion. There are no significant change in heart rate and blood pressure during infusion of NTG. These results indicate that intravenous NTG at 20 μg/min can inhibit platelet aggregation significantly in patients with coronary artery disease. No antiplatelet aggregative effect after continuing 24 hours of infusion of NTG indicates that tolerance was produced at platelet level.