国产氧氟沙星治疗细菌感染性疾病的临床评价

CLINICAL EVALUATION OF DOMESTIC OFLOXACIN IN TREATMENT OF BACTERIAL INFECTIONS DISEASES

氧氟沙星是抗菌谱广抗菌活性强的氟喹喏酮类药物新品种。本项研究随机用国产和进口氧氟沙星治疗细菌感染性疾病。剂量为200-300mg,每天2次,口服3-14d。在治疗伤寒副伤寒和呼吸道感染中,国产氧氟沙星组(47例)和进口氧氟沙星组(52例)临床有效率分别为93.6和94.2%。细菌消除率分别为89.8和87.5%。不良反应轻微。两组疗效比较无显著性差异(p>0.05)。国产氧氟沙星组(107例病人)总的有效率为89.7%,细菌消除率为89.2%。体外抗菌研究显示国产氧氟沙星对临床病例分离的细菌敏感率为91.7%,对细菌的MIC为0.03-1g/l。

Ofloxacin is a new broad-spectrum fluroquinolones. A randomized controlled clin-ical trial on domestic and imported ofloxacin was conducted in treatment of bacterial infections. Thedosage was 200-300 mg, twice daily orally for 3-14 days. In the treatment of typhoid and paratyphoidfever, respiratory tract infections, the clinical efficacy rates of domestic ofloxacin (47 patients) and im-ported ofloxacin (52 patients) were 93.6% and 94.2% respectively, the bacterial clearance rates of the twogroups were 89.9% and 87.5% respectively. The side effect of both groups were slight. There was nostatistical difference between the two drugs (p>0.05). The overall clinical efficacy rate of domesticofloxacin (107 patients ) was 89.7% and bacterial clearanced rate was 89.2%. Antibiotic sensitivitytest in vitro indicated that 91.7% of the strains isolated from patients were susceptible to domesticofloxacin with MICs ranging from 0.03 to 1.00 g/l.