老年骨质疏松与骨质增生症并存病人骨代谢生化指标及骨密度研究

Study on PTH,CT, BGP etc levels of senile osteoporosis with hyperosteogeny

本文对３５例老年骨质疏松症合并骨质增生病人及４０例不伴增生病人血甲状旁腺激素（ＰＴＨ）、降钙素（ＣＴ）、骨钙素（ＢＧＰ）、碱性磷酸酶（ＡＫＰ）、Ｃａ、Ｐ、Ｍｎ、Ｚｎ、Ｍｇ、Ａｌ等及骨密度（ＢＭＤ）进行检测。结果显示增生组ＰＴＨ、ＣＴ及ＢＧＰ均显著高于非增生组，增生组血Ｃａ、Ｍｎ水平均高于非增生组。经直线相关分析，增生组ＰＴＨ与ＣＴ之间ＰＴＨ、ＣＴ与ＢＧＰ之间具显著正相关。本文认为老年骨质疏松症合并骨质增生病人存在继发性甲状旁腺机能亢进和ＣＴ代偿性上升，其ＢＧＰ升高示骨转换和成骨细胞活性增高。

In the article, we observed the serum levels of Parathyroid Hormone (PTH),Calcitonin (CT), Osteocalcin (BGP), AKP, Ca, P, Mn, Zn, Mg, Al, etc in 35 elder patients who suffered from both osteoporosis and hyperosteogeny (20 male, 15 female, main age 66.7±5.2 years old)and 40 elder osteoporosis patients (none-hyperosteogenesis, 24 male, 16 female, main age 67. 8±6. 6 years old) . We adopted radioimmunoassay in assaying PTH-M, CT, BGP and Monophoton Absorption Scanning in doing Bone Mineral Density(BMD), and others, DCP-AES methods in doing the trace elements.The results showed that serum BGP, PTH, CT, Ca levels in the hyperosteogeny group were higher than those in none hyperosteogenesis group. In hyperosteogeny group, there were positive relativities between serum PTH and CT, PTH and BGP, serum BGP did relativity to CT.Aurther consider that these senile osteoporosis patients with hyperosteogeny demonstrated both hyperparathyroidism and tendency of CT increase, the increased levels of BGP suggest increased activities of osteoblast and bone turn over.