BMP促进去神经后废用性骨质疏松骨折愈合的实验研究

Experimental study about the effects of hone morphogenetic protein on fracture healing of post-denerve disused osteoporosis

为了观察ＢＭＰ对去神经后废用性骨质疏松性骨折愈合的作用，作考选用６月龄健康标准大鼠，严格配对分组，切除双侧坐骨神经后３周证实有明显骨质疏松。然后在腔骨人工骨折骨缺损处分别植入酸解胶状鼠尾胶原（对照）及ＢＭＰ与胶原混和物（实验组）。通过血清钙浓度、碱性磷酸酶活性及骨组织形态计量学多项参数的观察，显示ＢＭＰ对去神经后废用性骨质疏松骨折愈合有明显促进作用（Ｐ＜０．０５～０．０１）

In order to study the effects of bone morphogenetic protein(BMP) on the fracture healing of post-denerve disused osteoporosis, 20six-month-old SD Rats had been chosen for sciatic neurectomy. Then the rat model of disused osteoporosis were established after 3 weeks. 3mm tibia draft defects were created between Segments of upper 1/3 and middle 1/3. Defects of 10 rats were implanted with digested coloid abstracted from collagen of rat tails as control. The other 10 rats were implanted with mixture of the coloid and BMP as experimental group. Through the investigation on sera concentration of calcium, activity of sera alkaline phosphatase, and some indices of bone histomorphometry in the region of calllus ,which included trabecular volums. osteoid volums. osteoid surfaces osteoblastic surfaces ,mineralization rates, this study demonstrated that BMP could accelerated the bone fracture healing in postdenerve disused osteoporosis of rats.